Indocyanine green (ICG) isan FDA-approved near infrared fluorescence dye used in clinical imaging.However, its applications remain limited by rapid clearance, nonspecific plasmabinding, optical instability, and poor aqueous stability. Dye doped silica nanoparticlesprovide an effective barrier in keeping the dye away from the surroundingenvironment, but ICG could not be encapsulated into silica easily by conventionalmethods. In this study, anionic ICG molecules ion paired with a cationicpolymer polyethylenimine were successfully encapsulated into silica to form ICGdoped silica nanoparticles by St�ber's method. Pairing with PEI reduced selfquenching of fluorescence by preventing aggregation of ICG molecules in thecore of silica nanoparticles. Dye leakage was also reduced to the level of 15%loss in 4 d.

Near infrared dye indocyanine green doped silica nanoparticles
for biological imaging

240th National Meeting (2010)

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.

Near infrared dye indocyanine green doped silica nanoparticles for biological imaging