Our work has centred on efforts toward the total synthesis of the brasilinolide family of polyketide natural products which display immunosuppressive activity, antifungal activity and also anticancer activity.We have exploited substrate-controlled boron mediated aldol reactions, a unique epoxidation and reduction sequences to control all stereocentres of the full carbon scaffold.  This work will soon lead to the first total synthesis of all three congeners of this highly challenging natural product family.

Toward the total synthesis of the brasilinolides

240th National Meeting (2010)

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