Studies towards thepolycyclic core of palau'amine began with tetrahydobenzimidazoles derived froman intramolecular Diels-Alder reaction of a bis vinylimidazole. The cycloaddition product was modified withthe appropriate functionality to test an oxidative ring closing strategy formingthe B and D rings in the natural product prior to spirocyclization of the benzimidazole Figure 1. <img src='https://acs-archive-assets2.s3.amazonaws.com/239nm/uploads/6254_figure1.jpg' alt='' />.

Evaluation of
an oxidative BD-ring formation from a Diels-Alder derived pyrrole-imidazole
intermediate en route to the polyheterocyclic core of palau'amine

240th National Meeting (2010)

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Evaluation of an oxidative BD-ring formation from a Diels-Alder derived pyrrole-imidazole intermediate en route to the polyheterocyclic core of palau'amine