In this research effort, a family of cationic silicone polymers and monomers has been developed for application in contact lens materials.  These cationic amine functionalized silicone materials were successfully synthesized and incorporated into hydrophilic polymer matrices without formulation compatibility issues while still maintaining the high Dk property of siloxane chemistry.  This formulation of a silicone-based hydrogel provides for an inherently wetting surface of the contact lens and also allows for extraction of the material with just water instead of harsh organic solvents.  The described cationic silicone materials show great promise for future formulation efforts aimed at producing a contact lens with significantly reduced manufacturing cost.

Cationic silicones for use in contact lens applications

240th National Meeting (2010)

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