Dendritic macromolecules are versatile polymers for medical applications since the composition, structure, and molecular weight can be precisely tuned. We have reported the synthesis and characterization of polyester, polyester-ether, and polyamide dendrimers and dendrons composed of biocompatible building blocks. These macromolecules can be synthesized using either a divergent or convergent approach.  Subsequent crosslinking of these dendritic macromolecules using a photochemical acrylate-based or a chemical ligation strategy affords hydrogels.  The properties � mechanical, swelling, degradation, etc. � of the hydrogels can be tuned by altering the composition, crosslinking chemistry, wt%, generation number and so forth.  Theses dendrimers and hydrogels have been used successfully to repair corneal wounds.  These research accomplishments led to the formation of HyperBranch Medical Technology Inc (HBMT), the employment of fifteen people, the construction of a manufacturing facility, a number of toxicology and safety studies, and finally human trials.  HBMT has successfully developed and commercialized the ocular sealant � OcuSealTM, the first hydrogel sealant for repairing ocular wounds.

Dendritic
polymers for ocular wound repair: 
From concept to clinical use - the HyperBranch Medical Technology Story

240th National Meeting (2010)

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.

Dendritic polymers for ocular wound repair: From concept to clinical use - the HyperBranch Medical Technology Story