Nanotubes are emerging new systems for delivery of drugs and peptides to the tumors. We report on the synthesis of radiolabeled-US-tubes for imaging/therapy of cancer. US-tubes were loaded with radioisotopes (68Ga, 177Lu, 99mTc) and cold-Re manually or using automated-module-for-labeling, SmarTraceTM. Stability tests of labeled-US-tubes were performed to determine the desorption-half-life of the radioisotopes. 68Ga-labeling of US-tubes was completed in 0.5M NH4OAc. Yield of the synthesis was >70% at pH=3.6-4.1. 99mTc-labelling of US-tubes required the reduction with SnCl2. The final yield was >51% and decreased to 1% in the absence of SnCl2. 177Lu-labeling of US-tubes was performed in 0.1 M NH4OAc with yield >55%. US-tubes were loaded with cold-ReCl5 in the presence of base with yield >20%. Application of other Re-compounds ([NBu4]+ReOCl4-  or NH4ReO4) gave products with yield >17% or <0.4%, respectively. Our studies have shown that US-tubes can be loaded with imaging/therapeutic-isotopes to be used as vehicles in nuclear medicine.

Nanotubes as radiopharmaceuticals for cancer imaging and therapy

240th National Meeting (2010)

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