Type 1 (insulin-dependent) and type 2 (non-insulin-dependent) diabetes can lead to diabetic nephropathy, the most common cause of end stage renal disease.  The effects and progression of diabetes can be studied through the examination of the glomerulus in kidney cells, an organelle that aids in the removal of waste from the body.  The glomerulus becomes thickened and scarred as a result of diabetes damage ultimately leading to the alteration of the structure and functionality of the kidney.  In this study, trichrome-stained kidney sections were prepared from both non-diabetic and diabetic BBZDR/Wor rats up to fourteen months of age. Diabetes progression in these animals mimics type 2 diabetes in humans.  Kidney damage was analyzed independently through visual semi-quantitative estimation of overall sclerotic damage, glomerular damage, and quantitative measurements of glomerular diameters. A timeline was developed for measurable changes in kidney morphology during the progression of diabetes.

Progressive glomeruli damage in type 2 diabetic rats

241st National Meeting (2011)

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