Normalindividuals and especially those with Type 2 Diabetes or faced with obesity,often seek to decrease their sugar intake by consuming either natural orartificial alternative sweeteners to sugar.  Also desirable is a sweetenerthat can help decrease the absorption of additional dietary sugars when takensimultaneously.  Consumption of high levels of dietary simple sugarscan accentuate  �oxidative stress� due to toxic free radicals beingproduced.  Our lab has developed anunique cell model to simulate in vivo conditions of glucose absorptionwhich consists of a high glucose cell medium and epithelial cells.  Wehave compared 3 commercial sweeteners; Splenda, Truvia and Susta in thismodel.  All sweeteners lowered glucoseuptake and increased cellular antioxidant capacity but Susta was superior presumablydue its fiber and antioxidant content. In a separate experiment the fiber alone or antioxidants alone fromSusta were beneficial but the combination was most effective

Commercial sweeteners: Comparison of their effect on cellular antioxidant capacity
and glucose uptake

241st National Meeting (2011)

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Commercial sweeteners: Comparison of their effect on cellular antioxidant capacity and glucose uptake