Prostate cancer is the most common cancer in males and the third leading cause of death.  The TRAMP (transgenic adenocarcinoma of the mouse prostate) is widely used as an animal model of human prostate cancer.  Mice were fed low fat, high fat or high fat from walnut diets for 9, 18, or 24 weeks.  Mice fed the walnut supplemented diets had about 1/3 lower prostate weight at 18 weeks suggesting that the walnut diet suppressed tumor growth.  The liver was extracted by acidic or basic solvents and analyzed for metabolites by LC/MS.  There were 266 biochemicals identified and differences were found between levels of sphingolipids, w-3 fatty acids, arachidonic acid, lactate, oxidized fatty acids, and phospholipids.  Plasma low density lipoprotein was also lower in the walnut diet.  These results suggest that walnuts may suppress tumor growth through changes in lipid related pathways.

Walnut feeding changes hepatic metabolomic profile of mouse model of prostate cancer

241st National Meeting (2011)

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