Gold(I) complexes are the catalysts of choice for the selective activation of alkynes under mild conditions, which has been applied for the construction of complex cyclic systems. Thus, we have used the gold(I)-catalyzed cyclization of 1,6-enynes with carbonyl groups at the alkenyl chain for the synthesis of the sesquiterpenes orientalol F and englerin A. Recently we have found that the intermolecular reaction of alkynes with alkenes leads to cyclobutenes in the presence of cationic gold(I) catalysts bearing bulky phosphine ligands. Extension of these results for the macrocyclization of 1,n-enynes (n = 14) as well as results on the development of new gold(I)-catalyzed cyclization cascades will be presented.

Gold catalyzed
cyclizations and beyond

241st National Meeting (2011)

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.

Gold catalyzed cyclizations and beyond