Three-dimensional structures made of DNA hold the potential to encapsulate and release drugs, regulate the folding and activity of encapsulated proteins, selectively encage nanomaterials, and assemble 3D-networks for catalysis and biomolecule crystallization.  We will describe the synthesis of 3D-DNA structures, such as DNA cages and nanotubes, with deliberate variation of geometry, size, single- and double-stranded forms, permeability and persistence length.  These can be readily switched to different sizes, and can be 'opened' or closed with added DNA strands.  The size-selective encapsulation of nanomaterials within these nanostructures, and the release of this cargo when specific DNA strands are added will be shown.  Finally, the selective incorporation of transition metals within these structures will be described, in order to use DNA for the programmable positioning of different metals in three-dimensional space.  References:  Science 2008, 321, 1795; Nature Chem. 2010, 2, 320; J. Am. Chem. Soc. 2010, 132, 10212; J. Am. Chem. Soc. 2009, 132, 679; Angew Chem. 2009, 48, 9919; Nature Chem. 2009, 1, 390; Nature Nanotech., 2009, 4, 349; Angew Chem. 2008, 47, 2443; J. Am. Chem. Soc. 2007, 129, 13376; J. Am. Chem. Soc. 2007, 129, 10070; J. Am. Chem. Soc. 2007, 129, 4130.

3D DNA structures with moving parts: Loading and selective release of cargo for biological and materials applications

241st National Meeting (2011)

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