Over the past several years, we have begun to use interference microscopy to augment atomic force microscopy as a tool to the study the mechanics and dynamics of single live cells and groups of cells.   This technology is extremely well suited to capture motion on the micro- and even nano-scale, under certain conditions, with a temporal dynamic range and field of view that far exceeds scanning probe techniques.   We will present results showing the application of LCI to measurement of whole cell mechanical properties, label-free tracking of cytosol flows within cells and sub-pico gram-sensitivity, dynamic cell mass measurements.

Cells in motion: Live cell interferometry (LCI)

241st National Meeting (2011)

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