One potthree-component coupling methods have been developed to allow in situpreparation of fluoroalkylated arenes and hydrocarbon chain analogs. We havebeen investigating means to develop efficient coupling methodologies which (1)allow effective coupling of functionalized hydrocarbon chains onto readilyavailable arenes (2) where chain length and hybridization can be modified atease and (3) where the 18F can be introduced in situ at the final stage of the process. The methodology, whichis accelerated under microwave irradiation gives access to w-fluorinated alkyl, alkenyl, andalkynyl substituted arenes from readily available precursors. The methodologyinvolves late stage introduction of the fluorine and is well suited toapplication in the synthesis of 18F labeled PET imaging agents.

Microwave
accelerated three-component fluoroalkylations: Expeditious routes to
fluoropharmaceuticals and PET ligands

241st National Meeting (2011)

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