A particular derivative of ingenol is an anti-leukemic agent. This particular poster presents the synthetic methodology towards the ingenane skeleton with the crucial inside, outside-intrabridgehead stereochemistry. The IMDA reaction (scheme) was carried out with success showing after a subsequent transformation that ingenane skeleton with inside, outside-stereochemistry could have been formed along with three other products. We have only the GC trace with mass from GC-MS. However, it is clearly evident from the GC trace that one of the products should be the desired. The retrosynthetic analysis towards ingenane skeleton and the results will be presented 

Progress toward ingenane skeleton via IMDA reaction involving cycloheptadiene

241st National Meeting (2011)

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