General routes to the syntheses of totarol and viriditoxin will be discussed. Totarol is a diterpenoid natural product targeting the central bacterial cell division protein FtsZ that is isolated from Podocarpus totara. We have developed an asymmetric route to this molecule that enables new structural modifications for SAR studies. We have also completed the first synthesis of viriditoxin, which is isolated from an Aspergillus extract and also targets FtsZ. This is the first synthesis of a 6-6'-binaphthopyranone natural product and our route has also enabled the synthesis of related compounds in this class for future studies of FtsZ inhibition.

Synthetic studies of natural products targeting bacterial cell division

241st National Meeting (2011)

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