The Ala1-Gly28 glycopeptide domain of erythropoietin (EPO) has been prepared by chemical synthesis via a revised, more concise route. The shorter route is facilitated by a Lansbury Aspartylation between a 28 amino acid peptide and a complex dodecasaccharide. The route allows access to larger quantities of the glycopeptide domain as a single glycoform. 

Toward homogeneous erythropoietin: Revised chemical synthesis of the Ala1–Gly28 glycopeptide domain

241st National Meeting (2011)

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.