Flavonols are substancesfound in plants. These molecules are known to release carbon monoxide (CO) in adioxygenase-type reaction. Recently, a correlation of CO administration withreduced inflammation and vasodilation has shed light on the potential physiologicalbenefits of synthetic CO-releasing molecules (CORMs).  Our research is focused on examining how metal flavonolatecomplexes may be used as CO-release agents. In the work to be presented, wehave examined the chemistry of a zinc-flavonolate complex of a simple bidentateligand. Details of the synthesis and characterization, as well as theCO-release reactivity of this compound upon concurrent exposure to O2and light, will be reported. Reactivity comparisons will be made tozinc-flavonolate complexes that vary in terms of the supporting ligand.

Simple zinc-flavonolate complex: Synthesis, characterization, and CO-release reactivity

241st National Meeting (2011)

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