The click chemistry is a magnificent approach to an irreversible coupling of diverse chemical units. This irreversibility is a highly advantageous feature but it makes decoupling difficult. However, there is a plurality of situations requiring the decoupling of connected units. We propose a novel approach to connecting (marrying) molecules when there is a need for the future decoupling (divorcing) of the formed constructs. The methodology takes advantage of sacrificial chemical functionalities that are introduced using the click chemistry, stay in the construct as long as they are useful and they are cleaved when the coupled unit is not needed anymore. We call the proposed approach a MAD (marry and divorce) chemistry. The talk will discuss situations requiring the divorce of molecules and potential solutions using examples deriving from carbohydrate chemistry. Figure 1. <img src='https://acs-archive-assets2.s3.amazonaws.com/239nm/uploads/6313_acs_figure_sara.jpg' alt='' />

How to marry sugar molecules (misalliance included) using click chemistry? How to divorce them?

241st National Meeting (2011)

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