Our research focused on developing catalysts that could be used to change the reactivity of anionic intermediates in synthesis.  Specifically, we have been designing catalysts for reactions of carboxylate and nitronate anions.  These catalysts can bind the anion, and change the reactivity of the molecule as a whole.  Binding to the substrate allows for the possibility of defining the stereochemistry of the product, so this method can be useful for asymmetric additions.

Intermediate ion binding in stereoselective catalysis

241st National Meeting (2011)

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