Magnetic core-shell nanoparticles are widely used in basic research and clinical diagnostics. We focus on the application of these nanoparticles in cancer research and especially their potential in diagnosis and treatment of circulating tumor cells.We could show previously, that carboxymethyl dextran coated magnetic nanoparticles are a useful tool to separate circulating tumor cells from the peripheral blood. An interesting result of these separations is that vital circulating tumor cells are now available for further analysis, e.g. single cell RT-PCR or functional assays.After enrichment of the circulating cells the peripheral blood cells remain in the negative fration. We analysed the effect of magnetic core-shell nanoparticles on the survival of leukocytes in general and especially the lymphocytes as important parts of the immune system. In essence our enrichment procedure of circulating tumor cells from peripheral blood preserves the integrity and biological activity of leukocytes in the negative fraction.

Medical application of magnetic nanoparticles with polysaccharide shells

241st National Meeting (2011)

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