Despite the versatile ability of Layer by Layer (LbL) technique for generating multifunctional films on surfaces, its sensitive nature to any environmental changes reveals the limitations for use as a general platform for controlled release of a diverse range of biomolecules. Here, we report the conjugation of catechol groups largely present in mussel adhesive proteins to conventional polyelectrolytes with certain degree of substitutions, thereby preserving original cationic and anionic characters for use in LbL while mimicking the catechol derivatives which are responsible for two additional attractive interactions by hydrogen bonding and ?-? stacking. We also observe the catechol oxidative polymerization at an elevated pH (e.g. pH 7.4) by the formation of �COC- bonds. We conclude that these unique characters of catechol groups enable to reduce the mobility of individual polymer chains successfully preventing the interdiffusion phenomena and lead to accomplish a sustained release of experimental probes used.

Layer-by-layer assembly using catechol modified polyelectrolytes for enhance stability and sustained release of biomolecules: A bio-inspired approach

241st National Meeting (2011)

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