Wewill report on 3-D Nanosponges for controlled drug delivery and demonstrate theversatility of the intermolecular chain-crosslinking reaction utilizingchemistries that are tailored towards the properties of a wide variety oftherapeutics. So far, we successfully encapsulated small hydrophobic drugs thatcan be released in tailored release profiles governed by the tailoredcross-linking density of the nanosponges. The promising results in tumor regression studies have encouraged us tofind opportunities to extend the application potential to the delivery ofhydrophilic small molecules, peptides with secondary structures andproteins.  Here, we apply bioorthogonalcross-linking mechanisms that allow for the incorporation of peptides andgrowth factors during nanoparticle formation. We will present the synthesis oflinear polyester and polyacrylate precursors and cross-linking units that allowfor the bioorthogonal incorporation of high percentages of biologic structures.

Synthesis of degradable nanosponges via
intermolecular cross-linking utilizing bioorthogonal approaches

241st National Meeting (2011)

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Synthesis of degradable nanosponges via intermolecular cross-linking utilizing bioorthogonal approaches