Quantum dots (QDs) are nano-particles of semiconductor material such as zinc sulfide, cadmium sulfide, cadmium telluride, or cadmium selenide, with their overall structure being composed of a core surrounded by an outer shell.  The nature of QDs may be altered upon modification of or additions to this outer shell� including attachment of porphyrin molecules.  The resulting QD-porphyrin complex is expected to have increased photo- efficiency and more selective biological cell imaging.  Porphyrins are known to be tumor specific and therefore the QD-porphyrin complex should be as well.The porphyrin, H2TPPC, has been coupled to water-soluble QDs with an emission wavelength of 620 nm.  The protocol for synthesis, purification, and characterization of the QD-porphyrin complex, as well as the investigation  to cellular uptake of the QD-porphyrin complex will be discussed.

Development of a water-soluble QD-Porphyrin complex

241st National Meeting (2011)

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