Despite the tremendous accomplishments that have been described in the development of palladium- and nickel-catalyzed carbon�carbon bond-forming processes, it is nevertheless true that many significant opportunities remain.  For example, to date the overwhelming majority of studies have focused on couplings between two sp2-hybridized reaction sites (e.g., an aryl metal with an aryl halide).As of 2001, there were few examples of palladium- or nickel-catalyzed coupling reactions of alkyl electrophiles.  During the past several years, we have pursued the discovery of palladium- and nickel-based catalysts for coupling activated and unactivated primary and secondary alkyl electrophiles that bear � hydrogens.  Our recent efforts to develop broadly applicable methods, including enantioselective processes, will be discussed.

Palladium– and nickel–catalyzed coupling reactions of alkyl electrophiles

241st National Meeting (2011)

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