The study explores the ability of Photo-CuAAC technique to adjust and minimize the Cu concentration, optimize the initiation, and reaction rate to obtain high yield.The CuAAC reaction between 1-dodecyne and Ethyl azidoacetate catalyzed by the direct excitation of the Copper (II) complex to generate Copper (I). The disappearance of the azide peak upon irradiation by UVlight monitored by the FTIR for different concentrations of Cu(II)Cl2/PMDTAand fixed reactant concentrations in order to measure conversion. The resultshowed that as the Cu/PMDTA concentrations decreased, the yields of thereaction decreased. Additionally, the time required to complete the reactionincreased significantly as the Cu/PMDTA concentration decreased .These suggeststhat the Copper (I) is being consumed by side reactions after the reactionstarted. Future work will involve using different Copper (II) complexes as wellas different  photoinitiators in order to monitor the effects of initiation conditions on the generation of Copper(I).

Minimization of copper concentration and optimization of the initiation
and reaction rates for the photo-CuAAC reaction

242nd National Meeting (2011)

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