Nitroxide-mediated polymerization (NMP) has been successfully employed for the first time in the PEGylation landscape via the synthesis of polymer-protein/peptide bioconjugates. Well-defined and fluorescent N-succinimidyl ester functionalized poly(MePEGMA)-based copolymers were easily synthesized under SG1-control. They exhibited tunable reactivities towards nucleophiles depending on the nature of the alkoxyamine used. These a-functional copolymers are considered as an efficient platform for PEGylation purposes and represent a suitable alternative to previous systems synthesized by other polymerization techniques.

Design of innocuous polymethacrylates for biomedical applications by nitroxide-mediated polymerization

242nd National Meeting (2011)

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