The 4-amino-1,8-naphthalimide nucleus is a highly fluorescent moiety that is highly resistant to photochemical bleaching, and this suitable for applications in a wide range of fluorescence microscopy applications.  In the course of work designed to provide access to new derivatives of this fluorophore, we have discovered that the reactivity of the heterocyclic ring of these compounds is highly dependent on the substituent on the heterocyclic nitrogen.  The results of our studies in this area will be presented.

Unexpected reactions and reactivity of 4-amino-1,8-naphthalimide derivatives

242nd National Meeting (2011)

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