We synthesized a amphoteric poly(amino acid), Poly(?-glutamic acid) -graft-Arginine (?-PGA-Arg), to prepare a novel polyampholyte nanogels.  Arginine is one kind of cationic amino acid which can simply graft on the ?-PGA backbone in aqueous solution. In the case of 28% grafting degree of the ?-PGA-Arg, the sizes of nanogels were 632, 793, and 311 nm for the concentration with 10,5, and 1 mg/mL, respectively.In contrast, 32% grafting degree of nanogels were stable in the different concentration which sizes approximately were 200 nm. This result indicated that the size of polyampholyte gels can be changed by numbers of the ion namely that the balance of the cationic charged of Arg side chain and the anionic charged of ?-PGA unit. On the other hand, ?-PGA-Arg-44 could not form monodispersed naongels. We consider that the nanogels should regulate behavior of the protein adsorption by the surface charge.

Nano polyampholyte gels prepared by amphoteric poly (amino acid) for protein nanocarrier

242nd National Meeting (2011)

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