Engineered tissue grafts have the potential to repair damaged tissues when traditional transplants are unavailable or fail. Recent studies have utilized emulsion templating to generate novel microcellular polymers as biodegradable scaffolds for bone regeneration. Emulsion templating is a relatively new method for the production of high porosity scaffolds and involves the template polymerization of high internal phase emulsions (HIPEs). Although polyHIPEs have been investigated as potential bone grafts previously, biodegradable formulations often required toxic diluents to enable HIPE formation which precluded injectability of the system. In this study, propylene fumarate dimethacrylate (PFDMA) was selected as a biodegradable macromer with appropriate hydrophobicity and viscosity to enable HIPE formation without the need of a diluent. The effect of surfactant structural characteristics and concentration on HIPE formation and the resulting scaffold architecture (pore size) was investigated.

Injectable polyHIPEs as high porosity bone grafts

242nd National Meeting (2011)

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