The polymericnanoparticles have been extensively pursued for the development oftargeted-drug delivery systems. Herein, we present polymeric nanoparticles containingredox-sensitive moieties, which can be removed by chemically or enzymaticallytriggered reduction. Since the trimethyl lock-based functional groups undergothe triggered reduction to release a lactone and expose free hydrophilicfunctional groups, a class of trimethyl lock chemistry-based monomers were synthesizedand polymerized to obtain biodegradable polymers for the redox-sensitivenanoparticles. The alteration of physicochemical properties of the polymerinduced by the triggered reduction can dissemble the nanoparticles, whichfacilitates the release of entrapped chemicals. Nanoparticles were preparedfrom the redox-sensitive biodegradable polymers via an emulsion method. Thedynamic light scattering ensured that the size of nanoparticle significantlychanged upon chemical reduction with sodium hydrosulfite. In addition, thenanoparticles were challenged to a reductive enzyme frequently overexpressed incancer, DT-diaphorase, to release the lactone and the amounts of releasedlactone were quantitatively determined by HPLC. The nanoparticles that are ableto response to the triggered reduction would be promising as a drug deliveryplatform to target tumors.

Redox-sensitive polymeric nanoparticles

242nd National Meeting (2011)

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