Development of therapeutic delivery systems for controlled release requires characterization of a complex mixture of pharmaceuticals, delivery vehicle materials, and formulation components as well demonstrating the release properties of these systems.  The work in this talk illustrates the specific capabilities and advantages of different spectroscopic techniques developed in our laboratory to provide information about controlled release samples.  First, coupling infrared spectroscopy (IR) with the attenuated total reflection (ATR) sampling technique and fiber optic probe technology provides label free, non-destructive, chemical specific information about multi-component samples for use as a tool in the drug delivery field.  Second, steady state and lifetime fluorescence methods provide a sensitive measure of model pharmaceutical payload behavior.  These techniques are applied to two promising delivery vehicles, polymeric nanoparticles and hydrogels.

Spectroscopic methods for the development of nanomaterials for controlled release

242nd National Meeting (2011)

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