Chalcones (1,3-diphenyl-2-propen-1-one) are aromatic ketones that function as predecessors for many important biological compounds. The anticancer activity of chalcones has been found to be dependent on the presence, number, and positions of hydroxyl, methoxy, and halogen groups. Here we present the results of experiments to determine the effect of various 4 and 4'-monosubstituted chalcones and their respective isoxazoles on MCF-7 breast cancer cells and discuss the structure-activity relationship of the compounds.

Effects of various 4- and 4'-monosubstituted chalcones and their diaryl-isoxazole derivatives on MCF-7 breast cancer cell cultures

242nd National Meeting (2011)

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