Chemotherapeutic drugs are widely used for the treatment of cancer; however, use of these drugs is often associated with patient toxicity and poor delivery to the tumor. Poor delivery to the tumor can be attributed, in part, to rapid elimination of the drug by the reticuloendothelial system (RES), resulting in short circulation times. Nanoscopic drug carriers offer a promising approach to achieving improved delivery of chemotherapeutic drugs to tumors due to their size and ability to avoid RES uptake, but conventional nanoparticles are not stable in complex biological environments.  We will discuss the synthesis of a triblock copolymer designed to overcome the stability issue inherent in polymer micelles.  The physiochemical properties of the micelle, as well as in vitro and in vivo utility will also be presented.

Synthesis of triblock copolymers and development of a stabilized polymer micelle for drug delivery in oncology

242nd National Meeting (2011)

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