It has been notified the strengthening of bacterial efflux system and the decreased permeability of bacterial membranes toward antibiotics. These phenomena have enabled the rise of multi-drug resistant bacteria. Besides micro-organisms need for their development iron, so they synthesize molecules called siderophores which bind extracellular ferric iron and transport it into themselves. Interestingly some micro-organisms have developed ingenious bacteriostatic agent: a bioactive molecule is linked with a siderophore-like fragment. This �Trojan Horse�'s strategy is based upon the specific recognition by the bacteria receptors and the absorption allows to bypass bacterial membranes and heightens the antibacterial activity. To develop new therapeutic agents against multi-drug resistant bacteria, we decided to work on siderophore-linked antibiotics: an iron (III) chelator linked by a cleavable chemical bond to a therapeutic agent. We reported here the synthesis and biological results of catecholamides functionalized multi-amine backbone linked via a cleavable bond to a bioactive agent.

Bacterial iron's uptake: A promising solution against multidrug resistant bacteria

242nd National Meeting (2011)

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.