Kinetic resolutions and asymmetric reactions are two common means of creating enantiopure compounds.  Both of these methods have their own advantages and disadvantages and they are traditionally done independently of each other. We have combined these two asymmetric transformations together in sequence to quickly produce highly enantiomerically enriched compounds.  We will discuss the advantages of this methodology and how it has been applied to several chiral systems.

Combining asymmetric reactions and kinetic resolutions in one-pot

242nd National Meeting (2011)

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.