A three-component reaction that generates dihydro 2, 7-naphtyridin-1-ones has been developed. These unstable dihydro intermediates can either be oxidized or reduced to form naphtyridones or tetrahydro naphtyridones in good yields. The reaction tolerates a large variety of aldehydes and amines and the produced compounds are analogs of lophocladine A � a natural product with d-opioid receptor antagonist activity.1Reference:1. H. Gross et al., J. Nat. Prod. 2006, 69, 640-644.

Development of a three-component reaction forming naphtyridones: Synthesis of lophocladine analogs

242nd National Meeting (2011)

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