We present a facile and  straightforward method for the preparation of microcapsules with nanoparticle  shells. These capsules, called colloidosomes, are prepared on the basis of  Silica Ludox particles and stearic acid. In contrast to other known methods for  the preparation of colloidosomes, here, capsule formation can be carried out at  mild pH, ambient temperature with in-situ biomolecule loading and without the  use of hazardous chemicals. The incorporation and release of BSA, lysozyme,  fluorescine, luciferin and PEG into and from the capsules as well as the  influence of these molecules on capsule formation has been studied. While small  molecules are released almost instantaneously, molecules in the size of proteins  are released over the course of several weeks. The results indicate that  molecules that are negatively charged do not interfere with capsule formation  and can be successfully incorporated into the  capsules.

Assembly of submicron colloidosomes with silica nanoparticles featuring a selective permeability

243rd National Meeting (2012)

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.