Interactions of glycopolymers with cell surface lectins can be exploited in cell-specific biomedical materials, drug delivery systems and biological recognition substances. We have developed novel glycopolymers synthesized through modification of polyvinylamine (PVAm) backbone with galactose pendant groups. The interaction of this sugar modified polymer with a galactose responsive lectin from Ricinus communis agglutinin (RCA) was investigated using a Dissipative Quartz Crystal Microbalance (QCM-D). PVAm-g-galactose spontaneously bound to a variety of surfaces and the QCM-D measurements showed that the immobilized galactose specifically bound lectin.

Interaction of galactose modified polyvinylamine with lectin from Ricinus communis agglutinin

243rd National Meeting (2012)

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.