Model cell membranes can be used to pinpoint the molecular characteristics of certain molecules that enable them to interact with cell membranes in relation to medical purposes.  Langmuir Monolayers of phospholipids formed at an air-water interface allow for the measurement of molecular interactions by monitoring surface pressure as a function of molecular area.  Through the analysis of isotherm plots, non-ideal mixing, and compression moduli, these model membrane systems provide insight into the structural characteristics that enable cholesterol precursors to interact with inner leaflet lipids in relation to Alzheimer's Disease; the components in honey that result in its ability to act as an antibacterial agent; and the types of drug-delivery vehicles that are used.

Structure-function relationship: Importance of molecular interactions in cellular membranes investigated with Langmuir monolayers

243rd National Meeting (2012)

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