In this work, we have examined the growth and self-assembly of triazole derivatives and the binding affinity of those assemblies with metal nanoparticles and quantum dots was investigated. It was found that the triazole moiety played a significant role not only in the formation of the assemblies but also in binding to the nanoparticles. In general, depending upon the substituent chain length, the sizes of the assemblies were found to be in the range of 500 nm to 1mm. The assemblies efficiently bound to gold nanoparticles, as well as CdS nanoparticles. The binding of the nanoparticles to the assemblies was confirmed by absorbance, fluorescence as well as infra-red spectroscopy. Upon binding to the assemblies, the nanoparticles showed a red-shifts in fluorescence and absorbance spectra. Further, we examined the potential of the nanocomposites for antibacterial applications, where in it was found that the assemblies were potent against the gram negative bacteria e-coli. We also examined their interactions with mammalian cells. The nanocomposites were found to attach to the macrophages. In particular, the immunological response of the mouse macrophages was examined in the presence of the formed nanocomposites.

Self-assembly and growth of triazole based nanostructures and their interactions with mammalian cells

243rd National Meeting (2012)

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.