Surface-enhanced Raman spectroscopy (SERS) offers a way to capitalize on new nanomaterials for sensing applications. Here we present a glucose-binding Raman probe in conjunction with two SERS substrates: silver nanoparticles, and zinc-oxide nanowires decorated with gold nanoparticles. In each case, a glucose-dependent enhancement of the Raman signal is seen at physiological pH. The results are consistent with an electrostatically controlled interaction between probe and substrate.

SERS-based detection of glucose using a boronic-acid containing Raman probe

243rd National Meeting (2012)

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