The lack of selectivity and sufficient delivery of commonly used anticancer agents is a major cause of severe side effects and treatment failures. Our approach is to use zirconium phosphate (ZrP) nanoplatelet, an inorganic-layered nanomaterial, for targeted delivery of anticancer drugs to cancer cells and control release of drugs inside the cells in response to the acidic pH inside the cancer cells. We have illustrated this assertion by placing high levels of cisplatin and doxorubicin, respectively, within the layers. In-vitro studies with doxorubicin loaded ZrP nanoplatelets in breast cancer cell line (MCF-7) showed a threefold kill of cells after 24 hours and 20-fold death of the cancer cells after 48 hours of incubation with DOX:ZrP, compared with only doxorubicin. Similar results were obtained with cisplatin loaded ZrP and MCF-7 cells. The drug release is apparently due to the higher acidity of the cancer cells as opposed to normal cells.

BTHO cancer: Novel inorganic layered nanoplatelets for drug delivery in cancer nanotherapy

243rd National Meeting (2012)

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