Five years ago we began to study the effect of silver carbene complexes (SCCs) on a wide variety of cancer cells.  This research showed that SCCs are very effective against a variety of cancers including lung cancer.  A major focus of our research is now on the encapsulation of SCCs into nanoparticles for prolonged delivery to the lungs and for targeted systemic delivery. Encapsulation of SCCs within biodegradable polymeric nanoparticles is designed to protect the silver complexes from chloride and argyrophilic proteins in the blood there by allowing for systemic delivery.  Selective targeting of nanoparticles containg SCCs to cancer cells using folate and RGD is under investigation.

Anticancer properties of silver carbene complexes

243rd National Meeting (2012)

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