Non-activated alkyl halides are challenging substrates for cross coupling reactions because they are resistant to oxidative addition and because metal alkyl intermediate species are prone to beta-H elimination. Despite of recent progress in this area, the scope and utility of coupling reactions of alkyl halides are under-developed. We have prepared well-defined Ni catalysts that catalyze efficiently the coupling of non-activated alkyl halides with alkyl, aryl, heteroaryl, and alkynyl Grignard reagents. We have also explored the coupling between alkyl halides and C�H bonds using the same Ni catalysts. The mechanism of these Ni-catalyzed reactions is complex, but we have started to unveil a number of interesting mechanistic features. Besides reaction development, this talk will focus on some 'pure organometallic chemistry' aspects of our work in Ni catalysis.

Ni-catalyzed cross coupling of alkyl halides and direct C-H alkylation

243rd National Meeting (2012)

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.