Diaryliodonium salts, an important class of trivalent iodine reagents with two carbon ligands, are well known for their potential applications in photochemistry, organic chemistry and medicinal chemistry. The ability of diaryliodonium salts to form Cu(III) intermediates with Cu(I) catalysts in C-N cross coupling reactions pave the way for the rapid N-arylation of sulfoximines under eco-friendly conditions. The transformation was achieved by the reaction of sulfoximines with diaryliodonium salts in aqueous polyethylene glycol-400 with CuBr as the catalyst using ultrasound. The protocol was optimised by exploring different Cu(I) catalysts and green solvents (water, polyethylene glycol-400 etc.). The substrate scope, which was studied with various substituted sulfoximines and diaryliodonium salts, shows the generality of this procedure.

Hypervalent iodine reagents in the green synthesis of bioactive compounds

243rd National Meeting (2012)

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