Acylations of sulfonamides and amides are typically carried out by using acid chlorides and one equivalent of a strong base. Here we show initial studies into the use of lithium iodide as a catalyst for the coupling of acid chlorides to sulfonamides or amides to form the corresponding N-acyl product, eliminating the need for additional base.

Iodide catalysed acylations by acid chlorides

243rd National Meeting (2012)

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