Several important reactions in organic chemistry thrive on stoichiometric formation of phosphine oxides from phosphines. To avoid the resulting burden of waste and purification, cyclic phosphine oxides were evaluated for new catalytic reactions based on in situ regeneration. Therefore, the ease of silane-mediated reduction of cyclic phosphine oxides was explored.Dibenzophosphole oxides were found to be reducible under mild conditions and were selected for further applications in organophosphorus catalysis such as the catalytic Appel reaction and the Staudinger reduction.

Organophosphorus catalysis by in situ reduction of phosphine oxide

243rd National Meeting (2012)

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