We have obtained a series of small compounds and fully characterized their structures. These compounds can induce the structure change of nucleic acids. Some of them can regulate the structures of nucleic acid from double strand DNA to G-quadruple DNA.  Some of them can regulate the structure change of nucleic acid from B-DNA to Z-DNA. Further experiments provide strong evidence to support these results.

Design, synthesis, and structure regulation of small molecules

243rd National Meeting (2012)

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