Recent advances in production and application of native and designer cellulosomes and related systems for degradation of plant cell wall polysaccharides serve to forecast their employment for enhanced saccarification of cellulosic biomass en route to biofuels. Designer cellulosomes can be used as a convenient and effective tool for assessing the comparative effects of single enzymes and mutated derivatives within the cellulosome context. For this purpose, a wide range of CBM-, cohesin- and dockerin-bearing enzymes and/or scaffoldins can be produced at will and allowed to self-assemble into predetermined enzyme-containing complexes. Variations in cellulosome configuration and extension of the designer cellulosome concept provide unique systems for deconstruction of plant-derived polysaccharides. The talk will summarize recent approaches and results, using permutations and combinations of cellulosome-inspired systems.

Cellulosome-inspired systems for improved conversion of cellulosic biomass

243rd National Meeting (2012)

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