Abstract:  An N-halamine-based polymer additive was synthesized by reacting the potassium salt of 5, 5-dimethylhydantoin (DMH) with Poly (2-chloroethyl methacrylate) (PCLMA). The product was characterized by 1H NMR and EA analysis. The new polymer (DMH-PCLMA) was incorporated into cellulose acetate (CA) through solvent casting to serve as an antimicrobial additive. After chlorination treatment with diluted bleach, the resulting CA/Cl-DMH-PCLMA films provide a total kill of 106-107 CFU/mL of Escherichia coli (Gram-negative bacteria), Staphylococcus aureus (Gram-positive bacteria), and Candida albicans (fungi) within 1 hr.  In vitro biocompatibility was determined by rat skin cell viability analysis, which demonstrated that the presence of new the polymeric N-halamine-based additive did not negatively affect the biocompatibility of the CA films.

<i>N</i>-halamine based polymeric antimicrobial additive: preparation, characterization, antimicrobial activity, and biocompatibility

243rd National Meeting (2012)

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.

N-halamine based polymeric antimicrobial additive: preparation, characterization, antimicrobial activity, and biocompatibility